Constant light desynchronizes mammalian clock neurons.

Ohta H, Yamazaki S, McMahon DG
Nat Neurosci. 2005 8 (3): 267-9

PMID: 15746913 · DOI:10.1038/nn1395

Circadian organization can be disrupted by constant light, resulting in behavioral arrhythmicity or 'splitting' of rhythms of activity and rest. By imaging molecular rhythms of individual clock neurons in explanted mouse clock nuclei, we now find that constant light desynchronizes clock neurons but does not compromise their ability to generate circadian rhythms. Cellular synchrony within clock nuclei is disrupted during arrhythmicity, whereas neurons in the left and right clock nuclei cycle in antiphase during 'splitting.'

MeSH Terms (20)

Animals Behavior, Animal Biological Clocks Cell Count Chi-Square Distribution Circadian Rhythm Culture Techniques Diagnostic Imaging Eye Proteins Functional Laterality Gene Expression Regulation Green Fluorescent Proteins Light Mice Mice, Transgenic Motor Activity Neurons Period Circadian Proteins Suprachiasmatic Nucleus Time Factors

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