The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.

Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K, Cleveland JL, Grosveld GC
Mol Cell Biol. 2005 25 (6): 2395-405

PMID: 15743832 · PMCID: PMC1061619 · DOI:10.1128/MCB.25.6.2395-2405.2005

The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.

MeSH Terms (19)

Animals Apoptosis B-Lymphocytes Burkitt Lymphoma Cell Proliferation Child DNA-Binding Proteins Female Humans Male Mice Mice, Transgenic Mutation Proto-Oncogene Proteins c-ets Proto-Oncogene Proteins c-myc Suppression, Genetic Transcription Factors Tumor Suppressor Protein p53 Up-Regulation

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