Management of hypertension in the setting of autonomic failure: a pathophysiological approach.

Shibao C, Gamboa A, Diedrich A, Biaggioni I
Hypertension. 2005 45 (4): 469-76

PMID: 15738343 · DOI:10.1161/01.HYP.0000158835.94916.0c

We discuss 2 cases presenting clinically with disabling orthostatic hypotension and severe supine hypertension. This is a common presentation of autonomic failure, and one that challenges conventional treatment. Clinical findings of isolated autonomic failure were the most prominent manifestation in case 1, whereas a movement disorder was the key finding in case 2. The differential diagnosis and treatment of orthostatic hypotension is discussed from a pathophysiological approach. Understanding of the underlying mechanisms of disorders of the autonomic nervous system is fundamental for an effective management of these patients and provides insight into more common disorders such as essential hypertension.

MeSH Terms (10)

Aged Aged, 80 and over Autonomic Nervous System Diseases Diagnosis, Differential Female Humans Hypertension Hypotension, Orthostatic Male Supine Position

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