Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.

Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR
J Virol. 2005 79 (6): 3391-400

PMID: 15731233 · PMCID: PMC1075728 · DOI:10.1128/JVI.79.6.3391-3400.2005

MeSH Terms (15)

Amino Acid Substitution Animals Coronavirus Infections Disease Models, Animal DNA, Complementary DNA, Viral Mice Molecular Sequence Data Murine hepatitis virus Open Reading Frames Sequence Analysis, DNA Viral Nonstructural Proteins Viral Plaque Assay Virulence Virus Replication

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