[18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer.

Sasaki R, Komaki R, Macapinlac H, Erasmus J, Allen P, Forster K, Putnam JB, Herbst RS, Moran CA, Podoloff DA, Roth JA, Cox JD
J Clin Oncol. 2005 23 (6): 1136-43

PMID: 15718309 · DOI:10.1200/JCO.2005.06.129

PURPOSE - To determine whether the standardized uptake value (SUV) of [(18)F]fluorodeoxyglucose uptake by positron emission tomography could be a prognostic factor for non-small-cell lung cancer (NSCLC).

PATIENTS AND METHODS - One hundred sixty-two patients with stage I to IIIb NSCLC were analyzed. Overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local-regional control (LRC) were calculated by the Kaplan-Meier method and evaluated with the log-rank test. The prognostic significance was assessed by univariate and multivariate analyses.

RESULTS - There were 93 patients treated with surgery and 69 patients treated with radiotherapy. A cutoff of 5 for the SUV for the primary tumor showed the best discriminative value. The SUV for the primary tumor was a significant predictor of OS (P = .02) in both groups. Low SUVs ( 5.0; surgery group, P = .02; radiotherapy group, P = .0005). Low SUVs ( 5.0; stage I or II, P = .02; stage IIIa or IIIb, P = .004). However, using the same cutoff point of 5, the SUV for regional lymph nodes was not a significant indicator for DFS (P = .19), LRC (P = .97), or DMFS (P = .17). The multivariate analysis showed that the SUV for the primary tumor was a significant prognostic factor for OS (P = .03) and DFS (P = .001).

CONCLUSION - The SUV of the primary tumor was the strongest prognostic factor among the patients treated by curative surgery or radiotherapy.

MeSH Terms (18)

Adult Aged Carcinoma, Non-Small-Cell Lung Disease-Free Survival Disease Progression Female Fluorodeoxyglucose F18 Humans Lung Neoplasms Lymphatic Metastasis Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Positron-Emission Tomography Prognosis Retrospective Studies Survival Rate

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