Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans.

Thomas CD, Peters JC, Reed GW, Abumrad NN, Sun M, Hill JO
Am J Clin Nutr. 1992 55 (5): 934-42

PMID: 1570800 · DOI:10.1093/ajcn/55.5.934

To study the influence of diet composition on regulation of body weight, we fed 21 weight-stable subjects (11 lean, 10 obese) high-carbohydrate (HC) and high-fat (HF) diets for 1 wk each. Although diet composition was fixed, total energy intake was unrestricted. Subjects had a higher energy intake on the HF (11,039 +/- 2700 kJ/d) than on the HC (10,672 +/- 2617 kJ/d) diet (P less than 0.05), but energy expenditure was not different between diets. On day 7 of the HC diet, carbohydrate (CHO) oxidation was significantly related to CHO intake with the slope of the regression line 0.99, suggesting that overall CHO balance was near zero. However, the slope of the regression line was greater for obese than for lean subjects. On day 7 of the HF diet, fat oxidation was significantly related to fat intake but the slope of the line was 0.50, suggesting that overall fat balance was positive. However, this relationship was due entirely to lean subjects, with obese subjects showing no relationship between fat intake and oxidation.

MeSH Terms (17)

Adult Body Composition Body Weight Calorimetry Dietary Carbohydrates Dietary Fats Dietary Proteins Eating Energy Intake Energy Metabolism Female Humans Male Obesity Oxidation-Reduction Random Allocation Regression Analysis

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