Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease.

Zaja-Milatovic S, Milatovic D, Schantz AM, Zhang J, Montine KS, Samii A, Deutch AY, Montine TJ
Neurology. 2005 64 (3): 545-7

PMID: 15699393 · DOI:10.1212/01.WNL.0000150591.33787.A4

Dysfunction of neostriatal medium spiny neurons (MSNs) is hypothesized to underlie late-stage motor complications of Parkinson disease (PD). The authors demonstrate shortened dendrite length of MSNs that was similar in four regions of neostriatum in late-stage PD. In contrast, MSN dendrite spine degeneration was unevenly distributed with the greatest loss in caudal putamen. The authors propose that these structural changes in MSN may contribute to late-stage motor complications of PD.

MeSH Terms (10)

Aged Atrophy Dendrites Female Humans Male Middle Aged Neostriatum Neurons Parkinson Disease

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