Preoperative chemoradiotherapy prior to esophagectomy in elderly patients is not associated with increased morbidity.

Rice DC, Correa AM, Vaporciyan AA, Sodhi N, Smythe WR, Swisher SG, Walsh GL, Putnam JB, Komaki R, Ajani JA, Roth JA
Ann Thorac Surg. 2005 79 (2): 391-7; discussionn 391-7

PMID: 15680801 · DOI:10.1016/j.athoracsur.2004.08.045

BACKGROUND - Preoperative chemotherapy and radiation therapy are often administered to patients with esophageal cancer. Despite an aging population, little data exist regarding feasibility of preoperative therapy in elderly patients.

METHODS - Between January 1997 and December 2002, 312 consecutive patients underwent esophagectomy for esophageal cancer at our institution. Outcomes of patients 70 years old, who underwent preoperative therapy (n = 35; group II), were compared with those of patients who did not (n = 39; group I) and with those of patients younger than 70 years old who received preoperative therapy (n = 165; group III).

RESULTS - The median age was 75 years old for group I and 72 years for group II (p < 0.001). The patients in group II were of more advanced clinical stage (p < 0.001). There were no differences in performance status, comorbidities, or preoperative symptoms between the two groups. Similar proportions of patients in the groups I and II underwent a transhiatal approach (52.5% vs 42.8%, p = not significant [NS]). Perioperative mortality for groups I and II was 0% and 3%, respectively (p = NS). Group II received more perioperative blood transfusions (71.4% vs 48.7%, p = 0.047). There were no differences in the rates of postoperative cardiac, pulmonary, neurologic, gastrointestinal, or anastomotic complications. Compared with group III, group II patients had higher rates of postoperative atrial arrhythmias (p = 0.013) and perioperative blood transfusions (p = 0.004).

CONCLUSIONS - Elderly patients receiving preoperative therapy for esophageal cancer do not have an increased incidence of major postoperative complications. Elderly patients receiving preoperative therapy are more likely to develop postoperative atrial arrhythmias and require transfusion than younger patients.

MeSH Terms (26)

Adenocarcinoma Aged Aged, 80 and over Age Factors Antineoplastic Combined Chemotherapy Protocols Awards and Prizes Carcinoma, Squamous Cell Cardiovascular Diseases Chemotherapy, Adjuvant Comorbidity Diabetes Mellitus, Type 1 Esophageal Neoplasms Esophagectomy Female Follow-Up Studies Humans Length of Stay Male Multivariate Analysis Neoplasm Staging Premedication Pulmonary Disease, Chronic Obstructive Radiotherapy, Adjuvant Renal Insufficiency Retrospective Studies Survival Rate

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