Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation.

Bowman AB, Yoo SY, Dantuma NP, Zoghbi HY
Hum Mol Genet. 2005 14 (5): 679-91

PMID: 15661755 · DOI:10.1093/hmg/ddi064

MeSH Terms (14)

Animals Ataxin-7 Disease Models, Animal Genes, Reporter Intranuclear Inclusion Bodies Mice Nerve Tissue Proteins Neurons Peptides Photoreceptor Cells Proteasome Endopeptidase Complex RNA, Messenger Spinocerebellar Ataxias Ubiquitin

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