Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts.

Martin AM, Nolan D, James I, Cameron P, Keller J, Moore C, Phillips E, Christiansen FT, Mallal S
AIDS. 2005 19 (1): 97-9

PMID: 15627041 · DOI:10.1097/00002030-200501030-00014

Genetic (human leukocyte antigen), disease-related and demographic risk factors for nevirapine reactions were examined in a nevirapine-exposed cohort. Cases involving combinations of hepatitis, fever or rash were associated with an interaction between HLA-DRB1*0101 and the percentage of CD4, whereas no associations were detected for isolated rash. These data suggest that HLA-DRB1*0101 and the CD4 status may determine susceptibility to nevirapine hypersensitivity, consistent with a CD4 T-cell-dependent immune response to nevirapine-specific antigens.

MeSH Terms (13)

Adult Cohort Studies Drug Hypersensitivity Female Genetic Predisposition to Disease HLA-A Antigens HLA-DRB1 Chains HLA Antigens Humans Immunity, Cellular Male Nevirapine Reverse Transcriptase Inhibitors

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