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Impact of African herbal medicines on antiretroviral metabolism.

Mills E, Foster BC, van Heeswijk R, Phillips E, Wilson K, Leonard B, Kosuge K, Kanfer I
AIDS. 2005 19 (1): 95-7

PMID: 15627040 · DOI:10.1097/00002030-200501030-00013

We examined the effects of two African herbal medicines recommended for HIV/AIDS patients on antiretroviral metabolism. Extracts from Hypoxis and Sutherlandia showed significant effects on cytochrome P450 3A4 metabolism and activated the pregnane X receptor approximately twofold. P-glycoprotein expression was inhibited, with Hypoxis showing 42-51% and Sutherlandia showing 19-31% of activity compared with verapamil. Initiating policies to provide herbal medicines with antiretroviral agents may put patients at risk of treatment failure, viral resistance or drug toxicity.

MeSH Terms (15)

Anti-Retroviral Agents Aryl Hydrocarbon Hydroxylases ATP Binding Cassette Transporter, Subfamily B, Member 1 Cytochrome P-450 CYP3A Fabaceae Herb-Drug Interactions Humans Hypoxis Oxidoreductases, N-Demethylating Phytotherapy Plant Extracts Pregnane X Receptor Receptors, Cytoplasmic and Nuclear Receptors, Steroid Verapamil

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