A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.

Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL
J Pharmacol Exp Ther. 2005 313 (1): 199-206

PMID: 15608073 · DOI:10.1124/jpet.104.079244

MeSH Terms (29)

Amino Acids Amphetamine Animals Antipsychotic Agents ATP Binding Cassette Transporter, Subfamily B, Member 1 Behavior, Animal Benzamides Cell Line Central Nervous System Stimulants CHO Cells Cricetinae Dogs Excitatory Amino Acid Antagonists Female Haplorhini Humans Image Interpretation, Computer-Assisted In Vitro Techniques Microsomes, Liver Models, Statistical Motor Activity Phthalimides Radioligand Assay Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Reflex, Startle Xanthenes

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