Stromal fibroblasts in cancer initiation and progression.

Bhowmick NA, Neilson EG, Moses HL
Nature. 2004 432 (7015): 332-7

PMID: 15549095 · PMCID: PMC3050735 · DOI:10.1038/nature03096

It is widely accepted that the development of carcinoma--the most common form of human cancer--is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

MeSH Terms (8)

Animals Cell Transformation, Neoplastic Disease Progression Fibroblasts Humans Neoplasms, Glandular and Epithelial Signal Transduction Stromal Cells

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