Targeted molecular imaging agents for cellular-scale bimodal imaging.

Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ
Bioconjug Chem. 2004 15 (6): 1488-95

PMID: 15546219 · DOI:10.1021/bc049904q

Molecular imaging is a powerful tool that has the ability to elucidate biochemical mechanisms and signal the early onset of disease. Overexpression of the peripheral benzodiazepine receptor (PBR) has been observed in a variety disease states, including glioblastoma, breast cancer, and Alzheimer's disease. Thus, the PBR could be an attractive target for molecular imaging. In this paper, the authors report cellular uptake and multimodal (MRI and fluorescence) imaging of PBR-overexpressing C6 glioblastoma (brain cancer) cells using a cocktail administration approach and a new PBR targeted lanthanide chelate molecular imaging agent.

MeSH Terms (8)

Animals Cell Line, Tumor Drug Delivery Systems Nuclear Magnetic Resonance, Biomolecular Rats Receptors, GABA-A Spectrometry, Fluorescence Xenopus laevis

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