Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR
J Med Chem. 2004 47 (24): 5825-8

PMID: 15537338 · DOI:10.1021/jm049400d

MeSH Terms (17)

Allosteric Regulation Animals Antipsychotic Agents Benzamides Brain CHO Cells Cricetinae Cricetulus Glutamic Acid Humans In Vitro Techniques Pyrazoles Rats Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Reflex, Startle Structure-Activity Relationship

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