The power of pumping together; deconstructing the engine of a DNA replication machine.

Eichman BF, Fanning E
Cell. 2004 119 (1): 3-4

PMID: 15454074 · DOI:10.1016/j.cell.2004.09.023

The replicative DNA helicase lies at the heart of the eukaryotic replication machine, yet how it works remains puzzling. New structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nucleotide binding and hydrolysis powers conformation changes and DNA unwinding.

MeSH Terms (11)

Adenosine Triphosphate Animals Antigens, Polyomavirus Transforming Binding Sites DNA DNA Helicases DNA Replication Humans Hydrolysis Nucleotides Protein Structure, Tertiary

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