Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia.

Avison MJ, Nath A, Greene-Avison R, Schmitt FA, Bales RA, Ethisham A, Greenberg RN, Berger JR
J Neurovirol. 2004 10 (4): 223-32

PMID: 15371152 · DOI:10.1080/13550280490463532

Increased postcontrast enhancement in contrast-enhanced magnetic resonance imaging (CE-MRI) of the central nervous system (CNS) is a predictor of human immunodeficiency virus (HIV) dementia severity in HIV-infected subjects. The present study confirms this earlier finding in a mildly impaired patient cohort, and demonstrates that the increased postcontrast enhancement is correlated with increased cerebrospinal fluid (CSF) levels of monocyte chemoattractant protein (MCP)-1, an inflammatory chemokine, and increased CNS levels of mI, a microglial marker. These results suggest that early CNS inflammation may underlie the microvascular changes observed, and may be a factor in the development of HIV dementia.

MeSH Terms (14)

Adult AIDS Dementia Complex Antiretroviral Therapy, Highly Active Blood-Brain Barrier Cerebrovascular Circulation Cognition Female Humans Inflammation Male Microcirculation Middle Aged Patient Selection Treatment Outcome

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