NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter.

Huth JR, Yu L, Collins I, Mack J, Mendoza R, Isaac B, Braddock DT, Muchmore SW, Comess KM, Fesik SW, Clore GM, Levens D, Hajduk PJ
J Med Chem. 2004 47 (20): 4851-7

PMID: 15369388 · DOI:10.1021/jm0497803

MeSH Terms (19)

Binding Sites Combinatorial Chemistry Techniques DNA, Single-Stranded DNA-Binding Proteins DNA Helicases Drug Design Genes, myc Humans Inhibitory Concentration 50 Ligands Magnetic Resonance Spectroscopy Models, Molecular Promoter Regions, Genetic Protein Conformation Protein Structure, Tertiary Proto-Oncogene Mas Repetitive Sequences, Amino Acid RNA-Binding Proteins Structure-Activity Relationship

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