Protecting your tail: regulation of cadherin degradation by p120-catenin.

Kowalczyk AP, Reynolds AB
Curr Opin Cell Biol. 2004 16 (5): 522-7

PMID: 15363802 · DOI:10.1016/j.ceb.2004.07.001

Work in various model systems has yielded conflicting views of how p120-catenin participates in adherens junction assembly and regulation. A series of recent studies indicate that a core function of p120-catenin in mammalian cells is to regulate cadherin turnover by modulating the entry of cadherins into degradative endocytic pathways. By this mechanism, cellular levels of p120-catenin perform a 'rheostat' or 'set point' function that controls steady-state cadherin levels. These studies parallel a growing interest in the regulation of cadherin levels at the cell surface by membrane trafficking pathways. Collectively, the findings suggest exciting new roles for p120-catenin at the interface between cadherins and membrane trafficking machinery, and imply novel mechanisms by which p120-catenin may regulate cell adhesion and migration in the context of development and cancer.

Copyright 2004 Elsevier Ltd.

MeSH Terms (10)

Animals Cadherins Catenins Cell Adhesion Cell Adhesion Molecules Intercellular Junctions Models, Biological Phosphoproteins Protein Transport Transport Vesicles

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