Biphasic temporal pattern in exercise capacity after myocardial infarction in the rat: relationship to left ventricular remodeling.

Trueblood NA, Inscore PR, Brenner D, Lugassy D, Apstein CS, Sawyer DB, Colucci WS
Am J Physiol Heart Circ Physiol. 2005 288 (1): H244-9

PMID: 15358607 · DOI:10.1152/ajpheart.00042.2004

After myocardial infarction (MI), there is progressive left ventricular (LV) remodeling and impaired exercise capacity. We tested the hypothesis that LV remodeling results in structural and functional changes that determine exercise impairment post-MI. Rats underwent coronary artery ligation (n = 12) or sham (n = 11) surgery followed by serial exercise tests and echocardiography for 16 wk post-MI. LV pressure-volume relationships were determined using a blood-perfused Langendorff preparation. Exercise capacity was 60% of shams immediately post-MI (P < 0.05) followed by a recovery to near normal during weeks 5-8. Thereafter, there was a progressive decline in exercise capacity to +/-40% of shams (P < 0.01). At both 8 and 16 wk post-MI, fractional shortening (FS) was reduced and end-diastolic diameter (EDD) was increased (P < 0.01). However, neither FS nor EDD correlated with exercise at 8 or 16 wk (r(2) < 0.12, P > 0.30). LV septal wall thickness was increased at both 8 (P = 0.17 vs. shams) and 16 wk (P = 0.035 vs. shams) post-MI and correlated with exercise at both times (r(2) >/= 0.50 and P

MeSH Terms (12)

Animals Echocardiography Hypertrophy, Left Ventricular In Vitro Techniques Male Myocardial Infarction Physical Endurance Rats Rats, Wistar Time Factors Ventricular Function, Left Ventricular Remodeling

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