Validity of the child health questionnaire for use in children with sickle cell disease.

Panepinto JA, O'Mahar KM, DeBaun MR, Rennie KM, Scott JP
J Pediatr Hematol Oncol. 2004 26 (9): 574-8

PMID: 15342984 · DOI:10.1097/01.mph.0000136453.93704.2e

OBJECTIVE - To provide accurate data on health-related quality of life (HRQL), there must be a valid tool to measure this outcome. The objective of this study was to determine the validity of the Child Health Questionnaire (CHQ) as a measure of HRQL in sickle cell disease (SCD) by examining the relationship between HRQL and disease severity.

METHODS - This was a cross-sectional study of children conducted at two urban, hospital-based clinics. The study participants were children with SCD ages 5 to 18 years who presented for a routine visit to the comprehensive SCD clinic. The main outcome was HRQL, as measured by the CHQ-Parent Form 28 (PF28). A t test was used to compare HRQL between those with mild and severe disease.

RESULTS - Parents/caretakers of 95 children completed the CHQ-PF28. Children with mild SCD had a significantly better HRQL, as evidenced by a higher mean physical summary score (39.1), than those with severe disease (28.0) (difference=11.1, 95% confidence interval 5.03-18.11). There was no significant difference in psychosocial summary scores between groups.

CONCLUSIONS - The CHQ is a valid tool to assess HRQL in children with SCD and could serve as an important adjunct to determine the effect of SCD on the lives of children.

MeSH Terms (14)

Adolescent Anemia, Sickle Cell Child Child, Preschool Child Welfare Cross-Sectional Studies Female Health Status Health Status Indicators Humans Male Outcome Assessment, Health Care Quality of Life Surveys and Questionnaires

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