EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H
Proc Natl Acad Sci U S A. 2004 101 (36): 13306-11

PMID: 15329413 · PMCID: PMC516528 · DOI:10.1073/pnas.0405220101

MeSH Terms (14)

Adenocarcinoma Amino Acid Sequence Base Sequence Carcinoma, Non-Small-Cell Lung ErbB Receptors Erlotinib Hydrochloride Female Gefitinib Humans Lung Neoplasms Male Molecular Sequence Data Mutation Quinazolines

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