Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde-DNA adduct, N2-(3-oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2'-Deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin- 10(3H)-one (M1dG).

Riggins JN, Pratt DA, Voehler M, Daniels JS, Marnett LJ
J Am Chem Soc. 2004 126 (34): 10571-81

PMID: 15327313 · DOI:10.1021/ja040010q

MeSH Terms (9)

Catalysis Deoxyguanosine DNA Adducts Hydrogen-Ion Concentration Kinetics Nuclear Magnetic Resonance, Biomolecular Purines Pyrimidines Thermodynamics

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