Growth phase regulation of flaA expression in Helicobacter pylori is luxS dependent.

Loh JT, Forsyth MH, Cover TL
Infect Immun. 2004 72 (9): 5506-10

PMID: 15322055 · PMCID: PMC517482 · DOI:10.1128/IAI.72.9.5506-5510.2004

LuxS plays a role in the synthesis of an extracellular signaling molecule, autoinducer 2 (AI-2). To analyze a possible role of AI-2 in regulating Helicobacter pylori gene expression, we constructed a panel of transcriptional reporter strains. We show that the expression of H. pylori flaA is growth phase dependent and that flaA transcription increases in association with increased culture density. Mutating the luxS gene eliminates growth-phase-dependent control of flaA, and this growth phase dependence is restored when the luxS mutant strain is complemented with the wild-type luxS gene.

MeSH Terms (9)

Bacterial Proteins Carbon-Sulfur Lyases Culture Media Flagellin Gene Expression Regulation, Bacterial Helicobacter pylori Homoserine Lactones Mutation

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