Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.

Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL, Ding H, Elmore SW, Meadows RP, Olejniczak ET, Oleksijew A, Oltersdorf T, Rosenberg SH, Shoemaker AR, Tomaselli KJ, Zou H, Fesik SW
J Med Chem. 2004 47 (18): 4417-26

PMID: 15317454 · DOI:10.1021/jm040037k

MeSH Terms (21)

Animals Antineoplastic Agents Apoptosis Apoptosis Regulatory Proteins Binding Sites Breast Neoplasms Carrier Proteins Caspases Cell Division Cell Line, Tumor Humans Intracellular Signaling Peptides and Proteins Ligands Mice Mitochondrial Proteins Peptide Fragments Proteins Protein Structure, Tertiary Structure-Activity Relationship Transplantation, Heterologous X-Linked Inhibitor of Apoptosis Protein

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