Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines.

Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K
Chem Res Toxicol. 2004 17 (8): 1077-85

PMID: 15310239 · DOI:10.1021/tx049889d

MeSH Terms (19)

Animals Aryl Hydrocarbon Hydroxylases Breast Breast Neoplasms Cell Line, Tumor Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1 DNA Adducts Environmental Pollutants Epithelial Cells Female Humans Isomerism Nitro Compounds Oxidation-Reduction Pyrenes Rats Recombinant Proteins Tumor Cells, Cultured

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