Nuclear survivin as a biomarker for non-small-cell lung cancer.

Lu B, Gonzalez A, Massion PP, Shyr Y, Shaktour B, Carbone DP, Hallahan DE
Br J Cancer. 2004 91 (3): 537-40

PMID: 15266313 · PMCID: PMC2409840 · DOI:10.1038/sj.bjc.6602027

Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

MeSH Terms (20)

Aged Apoptosis Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung Cell Nucleus Cysteine Proteinase Inhibitors Cytoplasm Female Humans Immunohistochemistry Inhibitor of Apoptosis Proteins Lung Neoplasms Male Microtubule-Associated Proteins Middle Aged Neoplasm Proteins Prognosis Retrospective Studies Survival Analysis Survivin

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