The interface between cell and developmental biology.

Tahinci E, Lee E
Curr Opin Genet Dev. 2004 14 (4): 361-6

PMID: 15261651 · DOI:10.1016/j.gde.2004.06.013

Cell differentiation, morphology, migration, polarity, intercellular communication and adhesion are all cellular processes that control embryo morphogenesis and lie at the interface of cell and developmental biology. The interface between these two fields is best illustrated, however, in studies of axiation and cytoskeletal remodeling during development. Recent advances reveal novel mechanisms for axiation, including the role of RNA and protein degradation in regulating the timely expression of morphogenetic signals. Significant progress has also been made in identifying components of the cytoskeleton and the extracellular matrix that mediate embryonic cell migration and polarity. Cellular processes at the interface of cell and developmental biology are overseen by the Wnt signaling cascade that coordinates both axiation and cytoskeletal remodeling during development.

Copyright 2004 Elsevier Ltd.

MeSH Terms (9)

Animals Body Patterning Cytoskeleton Embryonic Development Extracellular Matrix Intercellular Signaling Peptides and Proteins Morphogenesis Signal Transduction Wnt Proteins

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