Membrane targeting: getting Arl to the Golgi.

Graham TR
Curr Biol. 2004 14 (12): R483-5

PMID: 15203023 · DOI:10.1016/j.cub.2004.06.017

Post-translational modification with myristoyl or prenyl groups is essential for membrane association of many small GTPases in the Ras superfamily. Two recent papers show that, rather than myristoylation, amino-terminal acetylation of the Arf-like protein Arl3p is required for Golgi targeting via an interaction with an integral membrane protein called Sys1.

MeSH Terms (9)

Acetylation ADP-Ribosylation Factors Golgi Apparatus Membrane Proteins Models, Biological Protein Processing, Post-Translational ras Proteins Saccharomyces cerevisiae Proteins Vesicular Transport Proteins

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