Calcium/calmodulin-dependent protein kinase II and synaptic plasticity.

Colbran RJ, Brown AM
Curr Opin Neurobiol. 2004 14 (3): 318-27

PMID: 15194112 · DOI:10.1016/j.conb.2004.05.008

A prominent role for calcium/calmodulin-dependent protein kinase II (CaMKII) in regulation of excitatory synaptic transmission was proposed two decades ago when it was identified as a major postsynaptic density protein. Since then, fascinating mechanisms optimized to fine-tune the magnitude and locations of CaMKII activity have been revealed. The importance of CaMKII activity and autophosphorylation to synaptic plasticity in vitro, and to a variety of learning and memory paradigms in vivo has been demonstrated. Recent progress brings us closer to understanding the regulation of dendritic CaMKII activity, localization, and expression, and its role in modulating synaptic transmission and cell morphology.

MeSH Terms (12)

Animals Calcium-Calmodulin-Dependent Protein Kinases Calcium-Calmodulin-Dependent Protein Kinase Type 2 Cell Differentiation Central Nervous System Dendrites Humans Memory Neuronal Plasticity Synapses Synaptic Membranes Synaptic Transmission

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