Long-term detrimental effect of bile duct injury on health-related quality of life.

Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, Chari R, Wright JK, Pinson CW
Arch Surg. 2004 139 (5): 476-81; discussion 481-2

PMID: 15136346 · DOI:10.1001/archsurg.139.5.476

HYPOTHESIS - Long-term quality of life (QOL) in patients undergoing laparoscopic cholecystectomy (LC) incurring bile duct injury (BDI) and repair is comparable to that of patients undergoing uncomplicated LC.

DESIGN - Case comparison study.

SETTING - Secondary and tertiary care centers.

PATIENTS - Eighty-six patients incurring BDI during LC between January 1, 1991, and July 31, 2003, were surveyed. Comparison subjects underwent uncomplicated LC during the same period.

MAIN OUTCOME MEASURES - Health-related QOL as assessed by the Karnofsky Performance Scale, Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and Psychosocial Adjustment to Illness Scale.

RESULTS - Fifty patients with BDI (39 [78%] female; mean +/- SEM age, 55 +/- 2 years) and 74 patients with uncomplicated LC (51 [69%] female, mean +/- SEM age, 52 +/- 2 years) responded. Of the 50 BDI patients, 48 (96%) had no stricture and normal liver function at QOL assessment. The mean +/- SEM follow-up period to QOL assessment for the BDI and uncomplicated LC groups was 62 +/- 6 and 47 +/- 3 months, respectively. The mean +/- SD Karnofsky Performance Scale scores were 77 +/- 9 vs 93 +/- 8 for the 2 groups, respectively (P <.001). The mean +/- SD SF-36 physical component scale scores after BDI vs uncomplicated LC were 36 +/- 11 vs 47 +/- 12, respectively (P <.001), compared with 50 +/- 10 for the normal population (P <.001). The mean +/- SD SF-36 mental component scale scores were 43 +/- 14 vs 49 +/- 11 for the 2 groups, respectively (P =.02), compared with 50 +/- 10 for the normal population (P =.01). Patients with BDI scored poorer on the Psychosocial Adjustment to Illness Scale health care orientation and domestic environment scales (P=.01).

CONCLUSION - After BDI and repair, there are long-term detrimental effects of BDI on health-related QOL.

MeSH Terms (12)

Bile Ducts, Extrahepatic Case-Control Studies Cholecystectomy, Laparoscopic Female Health Status Indicators Humans Intraoperative Complications Male Middle Aged Quality of Life Social Adjustment Treatment Outcome

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