Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response.

Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A
J Infect Dis. 2004 189 (10): 1811-20

PMID: 15122517 · DOI:10.1086/383277

To determine whether markers of T cell activation and maturation are independently predictive of the response to potent antiretroviral therapy, the Immunophenotypic Markers and Antiretroviral Therapy study applied a novel data-sharing strategy across 5 Adult AIDS Clinical Trial Group trials that counted naive and activated CD4(+) and CD8(+) T cells in 324 subjects. Regression models--adjustment for baseline CD4 cell count, human immunodeficiency virus (HIV) RNA, and study--revealed that high pretreatment CD8(+) T cell activation predicted virologic failure (P=.046). Additional models showed the greatest increase in CD4(+) T cell counts in subjects with highest pretreatment naive CD4(+) T cell counts (P<.0001), which was enhanced by high CD4(+) and low CD8(+) T cell activation. Total lymphocyte count also predicted a subsequent CD4(+) T cell change. These results document the utility of T cell markers in predicting treatment outcome and their potential value for the study and management of HIV-1 infection.

MeSH Terms (18)

Adult Anti-Retroviral Agents CD4 Lymphocyte Count CD8-Positive T-Lymphocytes Female Flow Cytometry Hemoglobins HIV-1 HIV Infections Humans Immunophenotyping Lymphocyte Activation Male Middle Aged Predictive Value of Tests Regression Analysis Reverse Transcriptase Polymerase Chain Reaction RNA, Viral

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