Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness.

Wagenknecht LE, Langefeld CD, Carr JJ, Riley W, Freedman BI, Moossavi S, Bowden DW
Stroke. 2004 35 (5): e97-9

PMID: 15073382 · DOI:10.1161/01.STR.0000127081.99767.1d

BACKGROUND AND PURPOSE - Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT).

METHODS - Calcified arterial plaque was measured in 2 vascular beds (coronary and carotid) by computed tomography, and common carotid artery IMT was measured by B-mode ultrasonography, in 438 participants.

RESULTS - Calcium was positively associated with IMT (r=0.36 for coronary and r=0.45 for carotid, both P<0.0001). Correlations were attenuated with adjustment for age, sex, and diabetes.

CONCLUSIONS - Calcified plaque in the coronary and carotid arteries is moderately associated with subclinical atherosclerosis.

MeSH Terms (19)

Adult Aged Arteriosclerosis Biomarkers Calcinosis Carotid Artery, Common Carotid Artery Diseases Carotid Stenosis Continental Population Groups Coronary Artery Disease Coronary Stenosis Diabetes Mellitus, Type 2 Female Humans Male Middle Aged Tomography, X-Ray Computed Tunica Intima Ultrasonography

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