Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues.

Biondi CA, Gartside MG, Waring P, Loffler KA, Stark MS, Magnuson MA, Kay GF, Hayward NK
Mol Cell Biol. 2004 24 (8): 3125-31

PMID: 15060136 · PMCID: PMC381682 · DOI:10.1128/MCB.24.8.3125-3131.2004

MeSH Terms (20)

Animals Embryo, Mammalian Exons Female Gene Silencing Hyperplasia Insulinoma Integrases Male Mice Mice, Inbred C57BL Mice, Knockout Multiple Endocrine Neoplasia Type 1 Pancreas Pancreatic Neoplasms Pituitary Gland Pituitary Neoplasms Prolactinoma Transgenes Viral Proteins

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