N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.

Bender RP, Lindsey RH, Burden DA, Osheroff N
Biochemistry. 2004 43 (12): 3731-9

PMID: 15035644 · DOI:10.1021/bi036107r

MeSH Terms (15)

Acetaminophen Antigens, Neoplasm Antineoplastic Agents Benzoquinones Cell Line, Tumor Chromosome Breakage DNA-Binding Proteins DNA Damage DNA Topoisomerases, Type I DNA Topoisomerases, Type II Etoposide Humans Imines Mutagens Topoisomerase II Inhibitors

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