Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.

Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD
Nat Neurosci. 2004 7 (4): 335-6

PMID: 15034587 · DOI:10.1038/nn1214

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

MeSH Terms (23)

Animals Arcuate Nucleus of Hypothalamus Down-Regulation Eating Energy Metabolism Feeding Behavior Female Hypothalamus Immunohistochemistry Male Mice Mice, Inbred C57BL Mice, Mutant Strains Neural Pathways Neurons Pro-Opiomelanocortin Proto-Oncogene Proteins c-fos Rats Rats, Sprague-Dawley Receptor, Melanocortin, Type 4 Satiety Response Sincalide Solitary Nucleus

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