The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.

Campbell UC, Lalwani K, Hernandez L, Kinney GG, Conn PJ, Bristow LJ
Psychopharmacology (Berl). 2004 175 (3): 310-8

PMID: 15024550 · DOI:10.1007/s00213-004-1827-5

MeSH Terms (15)

Animals Cognition Disorders Dose-Response Relationship, Drug Drug Synergism Hippocampus Male Maze Learning Memory Phencyclidine Pyridines Rats Rats, Long-Evans Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate Receptors, N-Methyl-D-Aspartate

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