Results of clinical trials with an allogenic melanoma tumor cell lysate vaccine: Melacine.

Sondak VK, Sosman JA
Semin Cancer Biol. 2003 13 (6): 409-15

PMID: 15001159 · DOI:10.1016/j.semcancer.2003.09.004

The identification of proteins and carbohydrates associated with melanoma led to development of defined antigen vaccines. However, vaccines derived from whole allogeneic cells have a number of advantages. Melacine is an allogeneic melanoma tumor cell lysate combined with an immunologic adjuvant, DETOX. Phase I and II trials in stage IV melanoma showed low-level antitumor activity, but this vaccine has its greatest promise in the adjuvant setting. A phase III trial indicated a survival benefit for Melacine in the subset of melanoma patients who express the HLA class I antigens A2 and/or HLA-C3. This finding must now be prospectively confirmed.

MeSH Terms (9)

Cancer Vaccines Clinical Trials as Topic HLA Antigens Humans Immunotherapy, Active Melanoma Neoplasm Staging Skin Neoplasms Treatment Outcome

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