The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.

Matsuoka TA, Artner I, Henderson E, Means A, Sander M, Stein R
Proc Natl Acad Sci U S A. 2004 101 (9): 2930-3

PMID: 14973194 · PMCID: PMC365722 · DOI:10.1073/pnas.0306233101

Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

MeSH Terms (20)

Animals Base Sequence Cell Line DNA Primers Gene Expression Regulation Humans Immunohistochemistry Insulin Islets of Langerhans Lectins, C-Type Maf Transcription Factors, Large Mice Molecular Sequence Data Organ Specificity Rats Receptors, Immunologic Recombinant Proteins Trans-Activators Transcription Factors Transfection

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