A phase I dose-escalation and pharmacokinetic study of brostallicin (PNU-166196A), a novel DNA minor groove binder, in adult patients with advanced solid tumors.

Lockhart AC, Howard M, Hande KR, Roth BJ, Berlin JD, Vreeland F, Campbell A, Fontana E, Fiorentini F, Fowst C, Paty VA, Lankford O, Rothenberg ML
Clin Cancer Res. 2004 10 (2): 468-75

PMID: 14760067 · DOI:10.1158/1078-0432.ccr-0658-03

MeSH Terms (15)

Aged Antineoplastic Agents Area Under Curve Calibration DNA Damage Female Guanidines Humans Kinetics Male Middle Aged Models, Chemical Neoplasms Pyrroles Time Factors

Connections (2)

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