The transforming growth factor-beta superfamily of receptors.

de Caestecker M
Cytokine Growth Factor Rev. 2004 15 (1): 1-11

PMID: 14746809

The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.

MeSH Terms (11)

Activins Animals Endosomes Gene Expression Regulation Humans Ligands Models, Biological Multigene Family Protein Binding Receptors, Transforming Growth Factor beta Signal Transduction

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