Olfaction: mosquito receptor for human-sweat odorant.

Hallem EA, Nicole Fox A, Zwiebel LJ, Carlson JR
Nature. 2004 427 (6971): 212-3

PMID: 14724626 · DOI:10.1038/427212a

Female Anopheles mosquitoes, the world's most important vector of Plasmodium falciparum malaria, locate their human hosts primarily through olfactory cues, but the molecular mechanisms that underlie this recognition are a mystery. Here we show that the Anopheles gambiae protein AgOr1, a female-specific member of a family of putative odorant receptors, responds to a component of human sweat. Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests.

MeSH Terms (15)

Animals Anopheles Cresols Drosophila melanogaster Electrophysiology Female Genes, Insect Humans Insect Repellents Neurons Receptors, Odorant Sex Characteristics Smell Substrate Specificity Sweat

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