Cell therapy of renal failure.

Fissell WH, Humes HD
Transplant Proc. 2003 35 (8): 2837-42

PMID: 14697917 · DOI:10.1016/j.transproceed.2003.10.008

The kidney is unique in that it is the first organ for which long-term ex vivo substitutive therapy has been available. The first hemodialyzer was successfully applied to a human patient with acute renal failure in 1948, and the first successful allograft transplantation was performed with a kidney in 1951. Both treatments are used today. There is ample evidence that the small solute clearance function provided by hemodialysis does not confer the same survival advantage as a functional kidney, both in acute and in chronic renal failure. To mimic the metabolic, endocrine, and immunologic functions of the kidney, our group has successfully engineered a bioartificial device that includes a conventional dialysis filter and a bioreactor containing 10(9) renal proximal tubule cells. We have demonstrated differentiated activity of these cells both in vitro and ex vivo in a large animal model. The bioreactor has been shown to confer a survival advantage in two large animal models of gram-negative sepsis, seemingly due to modulation of inflammatory mediators. This bioartificial kidney has now completed a Phase I clinical trial in acute renal failure.

MeSH Terms (9)

Animals Bioreactors Cell Transplantation Clinical Trials, Phase I as Topic Diabetic Nephropathies Humans Kidney Tubules, Proximal Models, Animal Renal Dialysis

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