Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes.

Lim CC, Zuppinger C, Guo X, Kuster GM, Helmes M, Eppenberger HM, Suter TM, Liao R, Sawyer DB
J Biol Chem. 2004 279 (9): 8290-9

PMID: 14676206 · DOI:10.1074/jbc.M308033200

MeSH Terms (22)

Animals Anthracyclines Antibiotics, Antineoplastic Apoptosis Calpain Caspase 3 Caspase Inhibitors Caspases Cells, Cultured Connectin Doxorubicin Enzyme Activation Enzyme Inhibitors Heart Ventricles Male Muscle Cells Muscle Proteins Myocardium Necrosis Protein Kinases Rats Rats, Sprague-Dawley

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