TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.

Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL
Proc Natl Acad Sci U S A. 2003 100 (26): 15548-53

PMID: 14657354 · PMCID: PMC307605 · DOI:10.1073/pnas.2536483100

MeSH Terms (16)

3T3 Cells Animals cdc25 Phosphatases Cell Cycle Cell Division Cell Line Epithelial Cells Female Intracellular Signaling Peptides and Proteins Mammary Glands, Animal Mice Phosphorylation Protein Serine-Threonine Kinases rho-Associated Kinases rhoA GTP-Binding Protein Transforming Growth Factor beta

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