Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.

Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD, Carroll M, Liu M, Osheroff N, Cheung NK, Slater DJ, Ried T, Knutsen T, Blair IA, Felix CA
Oncogene. 2003 22 (52): 8448-59

PMID: 14627986 · DOI:10.1038/sj.onc.1207052

MeSH Terms (16)

Adolescent DNA-Binding Proteins DNA Topoisomerases, Type II Histone-Lysine N-Methyltransferase Humans In Situ Hybridization, Fluorescence Leukemia, Myeloid, Acute Male Molecular Sequence Data Myeloid-Lymphoid Leukemia Protein Nuclear Proteins Protein Processing, Post-Translational Proto-Oncogenes Recombination, Genetic Transcription Factors Translocation, Genetic

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