Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues.

Lee LA, Orr-Weaver TL
Annu Rev Genet. 2003 37: 545-78

PMID: 14616073 · DOI:10.1146/annurev.genet.37.110801.143149

An intriguing aspect of cell cycle regulation is how cell growth and division are coordinated with developmental signals to produce properly patterned organisms of the appropriate size. Using the foundation laid by a detailed understanding of the regulators that intrinsically control progression through the cell cycle, links between developmental signals and the cell cycle are being elucidated. Considerable progress has been made using Drosophila melanogaster, both in identifying new cell cycle regulators that respond to developmental cues and in defining the impact of extrinsic signals on homologs of mammalian oncogenes and tumor suppressors. In this review, we discuss each cell cycle phase, highlighting differences between archetypal and variant cell cycles employed for specific developmental strategies. We emphasize the interplay between developmental signals and cell cycle transitions. Developmental control of checkpoints, cell cycle exit, and cell growth are also addressed.

MeSH Terms (6)

Animals Cell Cycle DNA Replication Drosophila melanogaster Mitosis Oocytes

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