N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity.

Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ
Proc Natl Acad Sci U S A. 2003 100 (23): 13674-9

PMID: 14595031 · PMCID: PMC263872 · DOI:10.1073/pnas.1835612100

MeSH Terms (20)

Allosteric Site Animals Brain Cell Line Clozapine Cricetinae DNA, Complementary Dose-Response Relationship, Drug Electrophysiology Guanosine 5'-O-(3-Thiotriphosphate) Hippocampus Humans Inhibitory Concentration 50 Mutagenesis, Site-Directed Neurons Protein Binding Rats Receptor, Muscarinic M1 Receptors, N-Methyl-D-Aspartate Time Factors

Connections (1)

This publication is referenced by other Labnodes entities:

Links