Regulation of beta-adrenergic responses in airway smooth muscle.

Shore SA, Moore PE
Respir Physiol Neurobiol. 2003 137 (2-3): 179-95

PMID: 14516725

Decreased responsiveness to beta-adrenergic receptor agonists is a characteristic feature of human asthma. This review summarizes data regarding the impact of chronic beta agonist stimulation, cytokines, prostanoids and other factors on beta-adrenergic responses in human airway smooth muscle, as well as the impact of polymorphisms of the beta(2)-adrenergic receptor on these responses. Effects of beta-agonists on both airway smooth muscle relaxation and gene expression are considered. Understanding the regulation of beta-adrenergic responses in airway smooth muscle cells may prove to be an important step in improving the efficacy of beta-agonists for the treatment of asthma.

MeSH Terms (9)

Adrenergic beta-Agonists Animals Asthma Bronchi Drug Resistance Humans Muscle, Smooth Receptors, Adrenergic, beta Trachea

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