Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits.

Bradshaw LA, Myers AG, Redmond A, Wikswo JP, Richards WO
Neurogastroenterol Motil. 2003 15 (5): 475-82

PMID: 14507349 · DOI:10.1046/j.1365-2982.2003.00432.x

We recorded the vector magnetogastrogram (MGG) due to gastric electrical activity (GEA) in normal rabbits using a Superconducting QUantum Interference Device (SQUID) magnetometer and measured the degree of correlation of the MGG with 24 channels of serosal electrodes. The vector magnetometer allows us to non-invasively record three orthogonal magnetic field components and project the recorded magnetic field vector into arbitrary directions. We optimized the magnetic field vector direction to obtain the highest possible correlation with each serosal electrode recording. We performed a vagotomy and examined spatial and temporal changes in the serosal potential and in the transabdominal magnetic field. We obtained spatial information by mapping the recorded signals to the electrode positions in the gastric musculature. Temporal evidence of uncoupling was observed in spectral analyses of both serosal electrode and SQUID magnetometer recordings. We conclude that non-invasive recordings of the vector magnetogastrogram reflect underlying serosal potentials as well as pathophysiological changes following vagotomy.

MeSH Terms (8)

Animals Electromagnetic Phenomena Magnetics Male Myoelectric Complex, Migrating Rabbits Vagotomy Vagus Nerve

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